Formulasi Micellar Based Water Ekstrak Bunga Telang

Muhammad Dzakwan

doi:10.30591/pjif.v9i2.2043

Formulasi Micellar Based Water Ekstrak Bunga Telang

Muhammad Dzakwan

Abstract

Clitoria ternatea is a twining herbal medicinal plant. It has pharmacological activity as antioxidant, anticancer and anti depressant. Extracts of C ternatea flowers were used as a component of cosmetics. The aim of this research is to formulate and develop micellar based water with variation concentration of amphiphilic polymer. Results showed that formulation containing amphiphilic polymer 1% (F5) is the most stable, clearly, particle size distribution of 46,67 nm and zeta potential -18,4 mV was obtained. Conclution, extracts of C ternatea flowers successfully formulaed to micellar based water, antioxidant activity (IC50) of 1,30 mg/ml was obtained.

Keywords

C ternatea of flower Extract Micellar Based Water Amphiphilic polymer Antioxidant

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References

.Douroumis D and Fahr A.,2013. Drug Delivery Strategies for Poorly Water-Soluble Drugs, Ed 1st, A John Wiley & Sons, Ltd., United Kingdom, 411-430.

Bansal M and Jamil S., 2018. Micellar Microparticles: A Novel Approach to Topical Drug Delivery System. Int J App Pharm, 10(5):1-5.

Makhmalzade B S and Chavoshy F., 2019. Polymeric Micelles as Cutaneous Drug Delivery System in Normal Skin and Dermatological Disorders, Journal of Advanced Pharmaceutical Technology and Research, 9(1): 2-8.

Miyata K, Christie J and Kataoka K., 2011. Polymeric Micelles for Nano-Scale Drug Delivery, Reactive and Functional Polymers, 71:227-234.

Patil A and Ferritto M S., 2014. Polymers for Personal Care and Cosmetics: Overview, ACS Symposium Series; American Chemical Society: Washington DC, 3-10.

Deshmukh A S, Chauhan P N, Noolvi M N, Chaturvedi K, Ganguly K and Shukla S S., 2017. Polymeric Micelles: Basic Research to Clinical Practice. Int J Pharm, 532: 249-268.

Oliveira B P P and Rodrigues F., 2018. Plant Extracts in Skin Care Products, MDPI St. Alban-Anlage 66 Basel, Switzerland, 34-40.

Jindal N. Mehta S K., 2015. Nevirapine Loaded Poloxamer 407/Pluronic P123 Mixed Micelles: Optimization of Formulation and In Vitro Evaluation. Colloids Surf. B Biointerfaces, 129: 100–106.

Ricardo N M P S, Ricardo N M P S, Costa F de M L L, Bezzera F W A, Chaibundit C, Merino D H, Greenland B W, Burattini S, Hamley I W, Nixon S K and Yeates S G., 2012. Effect of Water Soluble polymers, Polyethylene Glicol and Poly(Vinylpyrrolidone), on the Gelation of Aqueous Micellar Solutions of Pluronic Copolymer F127, Journal of Colloid and Interface Science, 368: 336-341.

Oliveira C P, Vasconcellos L C G, Ribeiro M E N P, Ricardo N M P S, Souza T V de P, Costa F de M L L, Chaibundit C and Yeates S G., 2011. The Effect of Polymeric Additives on the Solubilisation of Poorly Soluble Drug in Micellar Solutions of Pluronic F127, International of Journal Pharmaceutics, 409:206-208.

Samith V D, Mino G, Moore E R, Miranda N A., 2013. Effects of Pluronic F68 Micellization on The Viability of Neuronal Cells in Culture, J. Appl. Polym. Sci, 130(4): 2159–2164.

Tadros T F., 2015. Viscoelastic Properties of Sterically Stabilized Emulsiona and Their Stability. Adv. Colloid Interface Sci, 222: 692-708.

Bodratti A M and Alexandridis P., 2018. Formulation of Poloxamers for Drug Delivery, Journal of Functional Biomaterials, 9(11): 2-24.

Jadhav V, Deshmukh S and Mahadkar S.,2013. Evaluation of Antioxidant Potential of Clitoria Ternatea L, International Journal of Pharmacy and Pharmaceutical Sciences, 5(2): 595-599.

Nanasombat S, Thonglong J and Jitlakha J., 2015. Formulation and Characterization of Novel Functional Beverages with Antioxidant and Anti-Acetylcholinesterase Activities, Functional Foods in Health and Disease, 5(1):1-16.

Al-Snafi A S., 2016. Pharmacological importance of Clitoria ternatea – A review, IOSR Journal Of Pharmacy, 6(3): 68-83.

Sarumathy K, Dhana Rajan M S, Vijay T and Jayakanthi J., 2011. Evaluation of Phytoconstituents, Nephro-Protective and Antioxidant Activities of Clitoria ternatea, Journal of Applied Pharmaceutical Science, 01 (05): 164-172.

Lijon M B, Meghla N S, Jahedi E, Abdur Rahman M and Hossain I., 2017. Phytochemistry and Pharmacological Activities of Clitoria ternatea, International Journal of Natural and Social Sciences, 43(1):01-10.

Chakraborthy G S, Kumar V, Gupta S, Kumar A, Gautam N and Kumari L., 2018. Phytochemical and Pharmacological Aspects of Clitoria Ternatea- A Review, JAPSR, 1(2): 03-09.

Siti Azima A M, Noriham A and Manshoor N., 2014. Anthocyanin Content In Relation to The Antioxidant Activity and Colour Properties of Garcinia Mangostana Peel, Syzigium Cumini and Clitoria Ternatea Extracts, International Food Research Journal, 21(6): 2369-2375.

Kamkaen N and Wilkinson J M., 2009. The Antioxidant Activity of Clitoria ternatea Flower Petal Extracts, and Eye Gel, Phytotherapy Research, 23: 1624–1625.

Gupta G K, Chahal J and Bhatia M.,2010. Clitoria ternatea (L.): Old and New Aspects, Journal of Pharmacy Research, 3(11) : 2610-2614.

Yang O, Kim H L and Seo R K., 2015. Endocrine-Disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis, J. Cance Prevention, 20(1): 12-24.

Lu Y and Park K., 2013. Polymeric Micelles and Alternative Nanonized Delivery Vehicles for Poorly Soluble Drugs, Int J Pharm, 453:198-214.

Seedhler N and Kanojia M., 2008. Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note, AAPS PharmSciTech, 9(2): 431-43.

Tzankova V, Aluani D, Yordanov Y, Burdina M K, Petrov P, Bankova V, Simeonova R, Vitcheva V, Odjakov F, Apostolov A, Tzankov B and Yonccheva K., 2018. Micellar Porpolis Nanoformulation of High Antioxidant and Hepatoprotective Activity, Brazilian Journal of Pharmacognosi.

Baki G and Alexander K S., 2015. Introduction to Cosmetic Formulation and Technology, Ed 1st, John Wiley & Sons Inc, New Jersey, 15-45.

DOI: https://doi.org/10.30591/pjif.v9i2.2043