Polimorfisme P2Y12 Terhadap Agregasi Platelet Pada Pasien Penyakit Jantung Koroner

oktaviarika dewi hermawatiningsih

doi:10.30591/pjif.v8i2.1446

Polimorfisme P2Y12 Terhadap Agregasi Platelet Pada Pasien Penyakit Jantung Koroner

oktaviarika dewi hermawatiningsih

Abstract

Genetic polymorphism of P2Y12 receptor is one of the factors responsible for the variation in response to antiplatelet therapy. Variations in response to P2Y12 receptors can cause Coronary Artheri Disease (CAD) in CHD patients. This research was conducted in RSUD Sidoarjo East JavaÂ fromÂ NovemberÂ to December 2017 which aims to determine the effect of P2Y12 polymorphism on platelet aggregation in CHD patients. The research method used is Polymerase Chain Reaction (PCR) for P2Y12 genetic polymorphism and Light Transmittance Aggregometry (LTA) method for platelet aggregation measurement. From 30 samples, it was found that all samples had homozygot (wild type) type P2Y12 polymorphism with bp value of about 156 bp. Inferential analysisÂ was conductedÂ to determine the relationship between polymorphism of P2Y12 with platelet aggregation obtained p value = 0,130. From these results it can be saidÂ thatÂ between the genetic polymorphism of P2Y12 and platelet aggregation has no significant relationship.

Keywords : antiplatelet; clopidogrel; platelet aggregation; polymorphism P2Y12.

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DOI: https://doi.org/10.30591/pjif.v8i2.1446