Sintesis Senyawa APMS (Asam p-Metoksisinamat) dan Potensinya sebagai Antikolesterol

Rahmawati Salsa Dinurrosifa

doi:10.30591/pjif.v11i3.3926

Sintesis Senyawa APMS (Asam p-Metoksisinamat) dan Potensinya sebagai Antikolesterol

Rahmawati Salsa Dinurrosifa

Abstract

Kolesterol dalam tubuh sangat dibutuhkan, namun dalam jumlah yang sesuai kadarnya dan tidak melebihi batas normal. Kolesterol yang melebihi batas normal dapat memicu berbagai penyakit dalam tubuh seperti jantung koroner, diabetes melitus, gangguan tiroid, penyakit hepar, dan lain sebagainya yang dapat mengganggu aktivitas seseorang atau bahkan dapat menyebabkan kematian. Senyawa turunan asam sinamat terdapat hampir di semua tanaman yang dapat dikembangkan menjadi senyawa obat baru sebagai penurun kadar kolesterol. Asam p-metoksisinamat (APMS) merupakan senyawa turunan dari asam sinamat yang diduga memiliki aktivitas penurun kadar kolesterol.. Tujuan dari penelitian ini adalah untuk mengetahui penurunan kadar kolesterol dengan variasi konsentrasi dan melihat nilai effective concentration (EC₅₀) dari APMS. Analisis aktivitas penurunan kolesterol dilakukan berdasarkan metode Lieberman-Burchard dengan variasi konsentrasi 100 ppm, 200 ppm, 300 ppm, 400 ppm, dan 500 ppm. Hasil penelitian yang didapatkan menunjukkan aktivitas penurunan kadar kolesterol secara berurutan yaitu 42,76%, 46,60%, 49,04%, 52,36%, 56,90%. Nilai efektivitas (EC₅₀) yang didapatkan sebesar 313,85 ppm.

Cholesterol in the body is needed, but in appropriate amounts and does not exceed normal limits. Cholesterol that exceeds normal limits can trigger various diseases in the body such as coronary heart disease, diabetes mellitus, thyroid disorders, liver disease, and so on that can interfere with a person's activities or can even cause death. Cinnamic acid derivative compounds are found in almost all plants that can be developed into new medicinal compounds as cholesterol lowering agents. P-methoxycinnamic acid (APMS) is a compound derived from cinnamic acid which is thought to have cholesterol-lowering activity. The purpose of this study was to determine the decrease in cholesterol levels with variations in concentration and to see the value of the effective concentration (EC50) of the APMS. Analysis of cholesterol-lowering activity was carried out based on the Lieberman-Burchard method with various concentrations of 100 ppm, 200 ppm, 300 ppm, 400 ppm, and 500 ppm. The results obtained showed that the activity of reducing cholesterol levels was 42.76%, 46.60%, 49.04%, 52.36%, 56.90%. The effectiveness value (EC₅₀) obtained is 313.85 ppm

Keywords

kolesterol, Asam Sinamat, APMS, Lieberman-Burchard, EC50

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DOI: https://doi.org/10.30591/pjif.v11i3.3926